First Gene Therapy Successfully Slows Human Aging

American woman becomes biologically younger after receiving gene therapies.

In September 2015, then 44-year-old CEO of BioViva USA Inc. Elizabeth Parrish underwent two of her own company’s experimental gene therapies: one to guard against loss of muscle mass associated with aging, another to thwart stem cell diminution that causes diverse age-related diseases.

The treatment was originally proposed to establish the safety of the latest generation of gene therapies. But if early data is correct, it is already the world’s first positive outcome involving telomere lengthening by gene therapy in a human being. Gene therapy has been used to lengthen telomeres before in cultured cells and in mice, but never successfully before in a human patient.

Telomeres are short segments of DNA which surround the ends of every chromosome, acting as shields against wear and tear. They decrease in length with every cell division, ultimately becoming too short to protect the chromosome, causing the cell to breakdown and the body to age.

In September 2015, telomere data extracted from Parrish’s white blood cells by SpectraCell’s specialized clinical testing laboratory in Houston, Texas, immediately before therapies were administered, showed that Parrish’s telomeres were unusually short for her age, leaving her susceptible to age-related diseases earlier in life.

In March 2016, the same tests performed a second time by SpectraCell revealed that her telomeres had lengthened by approximately 20 years, from 6.71kb to 7.33kb, suggesting that Parrish’s white blood cells (leukocytes) have become biologically younger. These findings were independently confirmed by the Brussels-based non-profit HEALES (HEalthy Life Extension Company), and the Biogerontology Research Foundation, a UK-based charity committed to combating age-related diseases.

Parrish’s response: “Current therapeutics offer only marginal benefits for people suffering from diseases of aging. Additionally, lifestyle modification has limited impact for treating these diseases. Advances in biotechnology is the best solution, and if these results are anywhere near accurate, we’ve made history”, Parrish said.

BioViva will continue to examine Parrish’s blood for months and years to come. In the meantime, BioViva will begin testing new gene therapies and combination gene therapies to repair age related damage. Time will tell whether the success in leukocytes can be developed for other tissues and organs, and repeated in future patients.  Presently, all the answers reside in the cells of Elizabeth Parrish, “patient zero” of restorative gene therapy.

Since her first gene therapy injections, BioViva has attracted global interest from both the scientific and investment communities. Recently, BioViva became a portfolio company of Deep Knowledge Life Sciences (DKLS), a London-based investment fund which aims to fast-track production of biotechnologies for healthy longevity.

Dmitry Kaminskiy, founding partner of DKLS, observed, “BioViva has the potential to create breakthroughs in human gene therapy research, while leapfrogging companies in the biotech market.”

Facial Cosmetic Surgeon Dr. Oleh Slupchynskyj offers his patients the Stem Cell Facelift to promote facial rejuvenation. Schedule a consultation today.

Clinical Study on Ethnic Nasal Plastic Surgery Proves it May Have Helped Michael Jackson’s Self-Esteem

Dr. Oleh Slupchynskyj, published a ground-breaking study in 2008 that statistically proves a Cosmetic Rhinoplasty (Nose Job) procedure can result in very high patient satisfaction postoperatively and consistently increase self-esteem in African-American patients. Patients did not lose self-confidence because of Plastic Surgery.

Presidential candidate, Donald Trump stated about Michael Jackson, “He was an unbelievably talented guy. He lost his confidence. And he lost tremendous confidence because of, honestly, bad, bad, bad surgery.”

Dr. Slupchynskyj reports, “Although Mr. Trump is correct in stating that Michael Jackson had ‘bad surgery’, it is well documented that ‘Ethnic Rhinoplasty’ can increase the self-esteem of an individual. Like many celebrities, Michael Jackson chose poorly when it came to Plastic Surgeons and doctors in general, causing unacceptable Rhinoplasty results and possibly Mr. Jackson’s untimely death.”

According to the results of Dr. Slupchynskyj’s study, an overwhelming number of patients indicated average or above average satisfaction with their result. The high increase in self-esteem, considered with study results, indicates that Dr. Slupchynskyj’s technique as one that successfully addresses concerns of African-American patients seeking Rhinoplasty Surgery.

The Archives of Facial Plastic Surgery is the official publication for The American Academy of Facial Plastic and Reconstructive Surgery, Inc., The European Academy of Facial Plastic Surgery and The International Federation of Facial Plastic Surgery Societies.

Possible Overdiagnosis of Basal Cell Carcinoma in Elderly Patients

In the United States, over 2.5 million patients are diagnosed with Basal Cell Carcinoma (BBC), compared to 1.7 million other cancers. The majority of these BBCs develop in elderly individuals 65 years old and up; and every year more than 100,000 BBCs are treated in patients who will eventually die within a year. Over the past 15 years, Skin Cancer removal procedures have increased twofold; surgeons are opting to perform Mohs Surgery, histologically guided serial excision, and increased 400% between 1995 and 2009. Many physicians have implied that we are in the midst of a Skin Cancer epidemic caused by prolonged exposure to the sun, a thinning ozone layer and a rise in indoor tanning. These statics are apt to increase more, as the number of older adults doubles between 2010 and 2013, general Cancer occurrences are estimated to increase nearly 50%.

Regardless of these staggering numbers BBCs develop gradually, and treated BBCs rarely metastasize and are seldom lethal. Deaths from Basal Cell Carcinoma are extremely low, despite the fact that the number of patients diagnosed BBCs has increased drastically during the past 20 years. Non-Melanoma Skin Cancer mortality occurs in approximately 1 in 1,000 cases, but these deaths predominately result from Squamous Cell Carcinoma, not BBC. Patients diagnosed with BBC during their last year of life typically die of causes not related to these lesions.

Symptomatic vs. Screening Detected BBCs

Certain BBCs present with troublesome symptoms. Skin lesions can ulcerate, encumber the eyelids or ears, and result in itching, pain or bleeding in 12% of patients. When suffering from these symptoms, or evident tumors, patients usually make an appointment with their physician. For these patients, a Facial Cosmetic Surgeon is vital for presenting an accurate diagnosis and treatment plan for the offending tumors. Many BBCs go unnoticed by patients, usually identified by physicians during examinations.

Elderly patients have a higher possibility of being diagnosed with Basal Cell Carcinomas, but also present the utmost risk for unintended impairment. These may include: anxiety caused by a Cancer diagnosis, fear of metastasis or recurrence (though highly unlikely, or unpleasant side effects from treatment. Fragile elderly patients suffering from multiple, chronic conditions are more apt to grapple with Skin Cancer treatments, such as enduring long procedures, trouble with wound care and dressing changes, or ineffective wound healing.

Asymptomatic BBC treatment is necessary because they may grow, resulting in symptoms or necessitate extensive surgery in the future. Even though BBCs are classified as slow-growing tumors, how gradually an average BBC develops is equivocal. Will a tumor cause problems in decades, years or months? There is no clear-cut answer. Some patients indicate that they have had them for years before they become bothersome. Many Facial Cosmetic Surgeons would concur with the original observation by Jacob deduced in 1824, “…the slowness with which this disease proceeds is very remarkable.”

The Institute of Medicine recently recommended changes in Cancer treatment, emphasizing patient-focused communication and shared decision making as its main priority. Due to the ambiguity of the natural history of BBCs and their characteristically slothful disposition, patients with BBC will probably vacillate in their decisions to undergo biopsies or treatments. Especially, to assist sicker patients and their families make educated choices about slow-growing skin lesions, more facts and guidelines that integrate the risks and benefits of diagnosing, referring and treating these lesions are necessary.

If you suspect that you have Basal Cell Carcinoma or another type of Skin Cancer, schedule a consultation with Facial Cosmetic Surgeon Dr. Oleh Slupchynskyj to discuss treatment options and put your mind at ease.

How Far Should I Travel for Cosmetic Surgery?

Making the decision to have Plastic Surgery should not be taken lightly. There are plenty of fluffy, happy articles online and in magazines about the wonderful benefits of looking younger and more attractive via Cosmetic Surgery procedures, but those results are only possible when clients do their homework. Choosing the best Plastic Surgeon is imperative to getting the results you desire, and that can mean traveling outside of your local area.

Here are things to consider if you are trying to determine how far you should travel for Cosmetic Surgery.

Who is the best Plastic Surgeon I can afford?

Just as with any profession, there are amazing Plastic Surgeons and there are those with a less than desirable track record. When you make the decision to have a Facelift, Rhinoplasty, or other procedures that will permanently alter the way you look, you want the most experienced and qualified Plastic Surgeon at the helm. Do your research and study credentials, their reputation and reviews, and view plenty of before and after pictures. Ask for references. Do they have a specialty? For example, Dr. Slupchynskyj is known for his revolutionary Ethnic Rhinoplasty procedures, so many of our patients travel a long ways to ensure their Ethnic Rhinoplasty or Revision Surgeries are done by the best.

If the Plastic Surgeons in your area don’t make the cut (pun intended) then make the investment to travel to a surgeon who you trust will provide the most desirable outcome. In other words, you want to travel as far as you need to in order to have your procedure(s) performed by the best Plastic Surgeon you can afford.

How long can I take off work?

Many people are concerned that traveling will cause them to miss additional work time; however, this isn’t necessarily the case. With more major procedures, such as a full Facelift or Nose Job, we recommend that patients take 7 to 10 days off anyway to allow any swelling, bruising, or discomfort to fade and to allow the stitches to heal. Being away from home can often enhance the recovery period, because you are able to fully relax, rest, and recuperate. You will need to meet with the doctor at the one week mark to ensure your incisions are healing properly. Then you are free to return home.

Many of our patients travel from other states and make this their “vacation” for the year. Their families take advantage of all there is to do and see here and New York, and our patients return home looking better, and feeling more confident, than ever before.

Understand the risks of traveling abroad.

There has been a recent trend to travel abroad for Plastic Surgery procedures. We wholeheartedly recommend that you think twice before leaving the United States to have Cosmetic Surgery. In most cases, patients go abroad for Plastic Surgery because the procedures cost considerably less money. However, they are not taking into consideration the holistic costs of your safety and well-being. The United States has some of the most stringent medical regulatory measures of any country in the world. You want to ensure someone who is fully educated, trained and qualified, and adheres to the industry standards does your surgery. Your life is literally in their hands.

Dr. S. has performed countless revision surgeries to correct shoddy work done overseas. In these cases, the clients spend considerably more money, when you take into consideration their initial expenses for travel and procedure(s), and then add them to the cost of Revision Surgery, not to mention the pain and suffering that occurs in between. When you travel outside the country for your Cosmetic procedures, you are putting yourself at risk for poor quality care before, during, and after your surgery. You are also exposed to foreign contaminants and diseases that can compromise your immune system, which will further complicate your recovery period. It is always best to find a Board Certified Surgeon in the United States who comes highly regarded.

Don’t Let Finances Keep You from Visiting the Best Plastic Surgeon Available

Never let finances get in the way of a top-notch Plastic Surgery procedure. Investing in the best possible outcome is well worth it. If finances are the only thing keeping you from having your Cosmetic Surgery procedures performed by a reputable surgeon, ask their office about financing options. Dr. Oleh Slupchynskyj is one of the best Plastic Surgeons, and our office offers a variety of financing options to ensure you receive the high-quality procedures you deserve.

Contact us today to schedule your consultation, and begin making your travel plans for a Plastic Surgery procedure that will be done expertly the first time around.

The Benefits of Asian Rhinoplasty

Asian Nose Surgery

Asian Nose Job

Asian Nose Job

Asian Nose Surgery, or Asian Rhinoplasty, is one of the most popular Cosmetic Surgery procedures in Dr. Oleh Slupchynskyj’s practice. A wide variety of his patients request sophisticated, distinctive results. Naturally, the perception of what is regarded as “beautiful” changes with time and with the influence of other cultures on one’s own. Cultural mixing between Asia and the Western world has influenced what patients consider an ideal nose in various countries. Many Asians think an attractive nose is one where the nasal dorsum is augmented and nasal tip is slightly more accentuated than one that is typically “natural looking” for a person of Asian descent.

The Asian nose has several distinguishing features when compared to the Caucasian nose or one of European descent. The Asian nose usually possesses thicker skin, with a deeper and flatter radix, and a lower or sometimes depressed nasal bridge. The tip of the nose tends to have a broad dome, while both the tip and the nostrils can be thicker skinned, wider, and have more fibro-fatty tissue than the Caucasian nose. The columella, or underside of the nose, also tends to be minimal.

Previously, the standard has been for Plastic Surgeons, typically General Plastic Surgeons, to perform Rhinoplasty on all patients in the same exact way regardless of their ethnicity. This made the noses of ethnic clients appear unnatural and unbalanced when compared to their other facial features and physical characteristics. Dr. Oleh Slupchynskyj, a New York City Rhinoplasty Surgeon and Dual Board Certified Facial Plastic Surgeon believes Asian Rhinoplasty, similar to many Ethnic Rhinoplasty surgeries he performs, requires advanced surgical skills that enable him to achieve very unique, custom-tailored results.

When an Asian patient considers Rhinoplasty, they typically are looking for more refined and augmented bridge, (i.e. slightly thinner and higher bridge). A more refined tip with increased projection is also popular. Adding definition to the bridge of the nose is often desired, in order to increase prominence in a natural way that is balanced to the rest of their face. Asian noses commonly have delicate cartilage, requiring superior skill to manipulate when making any alterations. The nasal bridge of an Asian person should start at or below the eyelashes, rather than higher towards the forehead as do many Caucasian noses.

Augmentation of the nasal bridge is best achieved by using the patient’s cartilage from the nasal septum or from the ears. Should the donor cartilage be insufficient or too flimsy for proper sustained augmentation, Dr. Slupchynskyj’s customized Silastic implant is advocated, as it is well tolerated by Asian noses, due to their thicker skin. Dr. Slupchynskyj’s surgical technique ensures the custom silastic implant is placed in the correct tissue plane and is sutured into place. Dr. Slupchynskyj never uses Medpor implants due to the known associated risks with this nasal implant. Dr. Slupchynskyj, an Asian Revision Rhinoplasty Specialist, has addressed various complications arising from tissue in-growth with Medpor implants, placed by another surgeon during Asian Rhinoplasty.

Lip Augmentation in NYC

Just like the rest of the face, the lips are susceptible to unwanted changes due to aging. Over time, they lose volume and change shape, and can also be affected by wrinkles around the mouth. When this happens, women in particular may become self-conscious about the appearance of their lips. Board Certified New York City Facial Plastic Surgeon Dr. Oleh Slupchynskyj offers revolutionary Lip Augmentation treatment techniques that go beyond the traditional injections and filler methods to produce beautiful, long-lasting and natural-looking results. Under his expert surgical hand and keen eye, many NYC lip augmentation patients have attained youthful, voluminous lips they desire.

What is Lip Augmentation Surgery?

Lip Augmentation Surgery at Dr. Slupchynskyj’s New York practice is different from other Lip Enhancement procedures. Unlike other procedures which use temporary injectable fillers to create volume, Lip Augmentation Surgery is a permanent solution, which improves the look of a patient’s own lips. Rather than use synthetic implants, Dr. Slupchynskyj raises the location of the upper lip, exposing more pink lip area and creating a wider, healthier looking smile. Dr. Slupchynskyj may supplement the final result using fillers such as Juvederm®™; however, the most visible and attractive results come as a result of his unique surgical techniques. Dr. Slupchynskyj knows that bigger doesn’t always mean better when it comes to Lip Augmentation. He evaluates other facial features before performing Lip Augmentation Surgery so that he can create results that provide a favorable, youthful look.

How is Lip Augmentation Surgery performed?

Dr. Slupchynskyj uses several surgical techniques for Lip Augmentation in NYC. During a thorough pre-surgery consultation, he will evaluate the patient’s existing lip shape, underlying dental work and jawline, as well as other facial features to determine which treatment approach is best suited for them. All Lip Augmentation Surgeries are performed under local anesthesia.

Recovering from Lip Augmentation Surgery

New York City Lip Augmentation patients may experience minor swelling, stiffness and discomfort immediately following surgery. Dr. Slupchynskyj provides detailed post-operative instructions to all patients to ensure a speedy, safe recovery. He will also prescribe medications to manage any pain or risk of infection after surgery. Patients should apply cold compresses to the lips the first few days after surgery. Most Lip Augmentation patients recover fully 10 days after the procedure.

The Benefits of Lip Augmentation Surgery

Lip Lift Surgery can be performed on its own or as the finishing touch to a complete facial rejuvenation treatment. The procedure can restore a patient’s youthful appearance and reduce or eliminate the appearance of wrinkles around the mouth. Dr. Slupchynskyj’s approach to Lip Augmentation is particularly beneficial because it is a safer, more natural-looking treatment. Surgical lip enhancement is a more permanent solution than injectable fillers or fat injections alone. The procedure can be completed in about one hour, but can make years’ worth of difference in a patient’s appearance.

Schedule a Lip Augmentation Consultation in New York Today

Dr. Oleh Slupchynskyj is a renowned New York City Lip Lift and Facial Plastic Surgeon. He takes great pride in helping patients enhance their appearance and self-confidence through aesthetic procedures. To learn more about how Lip Augmentation can help you look your best, schedule a consultation with Dr. Slupchynskyj today by calling
(212) 628-6464.

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